Knobloch is Senior Physicist at the European Organization for Nuclear
Research (CERN) in Geneva, Switzerland.
From 1969 to 1976 he was physicist at DESY and obtained PhD on "Deep Iinelastic Electron Scattering in a Streamer Chamber".
Since 1976 he was research physicist in the experiments CDHS, ALEPH and ATLAS at CERN (co-) authoring some 250 scientific articles.
In the CDHS neutrino experiment he worked on nucleon structure functions and precise measurement electroweak parameters.
In the ALEPH experiment at the electron-positron collider LEP he participated in the design of the detector and led the development of the reconstruction and analysis software.
In ALEPH and later in the ATLAS experiment at the Large Hadron Collider (LHC) with its more than 2000 scientists he was nominated Computing Coordinator overseeing the software development and the computing infrastructure.
Since 2000 he headed groups in CERN's IT-Department developing common physics analysis software systems for the experiments at CERN. From 2001 to 2010 he was member of scientific committees (SPSC, LHCC) at CERN.
He prepared the general computing infrastructure of the LHC experiments in the framework of European computing grid projects. In the LHC Computing Grid project he was the editor-in-chief of the LHC Computing Grid Technical Design Report published in 2005. Since 2007 he led the CERN participation in the European Grid Initiative (EGI) Design Study becoming the technical director of the project. He edited the “EGI-Blueprint” as basis of the EGI foundation.
In recent years he had promoted the use of particle physics simulation software in other domains such as space exploration and medical applications.
Since 2008 he is editor of the IEEE Transactions on Nuclear Science Journal.
Since 2010 he is retired from CERN and has the status of Honorary Staff Member of CERN.